Publication: Vitamin D3 and its nuclear receptor increase the expression and activity of the human proton-coupled folate transporter
Vitamin D3 and its nuclear receptor increase the expression and activity of the human proton-coupled folate transporter
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Eloranta, J. J., Hiller, C., Hausler, S., Stieger, B., & Kullak-Ublick, G. A. (2009). Vitamin D3 and its nuclear receptor increase the expression and activity of the human proton-coupled folate transporter. Molecular Pharmacology, 76(5), 1062–1071. https://doi.org/10.1124/mol.109.055392
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Folates are essential for nucleic acid synthesis and required particularly in rapidly proliferating tissues, such as intestinal epithelium and hemopoietic cells. Availability of dietary folates is determined by their absorption across the intestinal epithelium, mediated by the proton-coupled folate transporter (PCFT) at the apical enterocyte membranes. Whereas transport properties of PCFT are well characterized, regulation of PCFT gene expression remains less elucidated. We have studied the mechanisms that regulate PCFT promoter activ
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- Eloranta, J J
- Hiller, C
- Hausler, S
- Stieger, B
- Kullak-Ublick, G A
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Eloranta, J. J., Hiller, C., Hausler, S., Stieger, B., & Kullak-Ublick, G. A. (2009). Vitamin D3 and its nuclear receptor increase the expression and activity of the human proton-coupled folate transporter. Molecular Pharmacology, 76(5), 1062–1071. https://doi.org/10.1124/mol.109.055392
