Publication: Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols
Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols
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Haenseler, W., Eschment, M., Evans, B., Brasili, M., Figueiro-Silva, J., Roethlisberger, F., Abidi, A., Jackson, D., Müller, M., Cowley, S. A., & Bachmann-Gagescu, R. (2025). Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols. Frontiers in Cell and Developmental Biology, 13, 1516596. https://doi.org/10.3389/fcell.2025.1516596
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Introduction: Ciliopathies are a group of human Mendelian disorders caused by dysfunction of primary cilia, small quasi-ubiquitous sensory organelles. Patients suffering from ciliopathies often display prominent neurodevelopmental phenotypes, underscoring the importance of primary cilia during development and for function of the central nervous system (CNS). Human tissues, in particular from the CNS, are very hard to obtain for research. Patient derived- or genetically engineered human induced pluripotent stem cells (hiPSCs) are there
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Haenseler, W., Eschment, M., Evans, B., Brasili, M., Figueiro-Silva, J., Roethlisberger, F., Abidi, A., Jackson, D., Müller, M., Cowley, S. A., & Bachmann-Gagescu, R. (2025). Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols. Frontiers in Cell and Developmental Biology, 13, 1516596. https://doi.org/10.3389/fcell.2025.1516596
