Influence of non-steroidal anti-inflammatory drugs (NSAIDs) on osseointegration of dental implants in rabbit calvaria

Cai, Wei Xin; Ma, Li; Zheng, Li Wu; Kruse-Gujer, Astrid; Stübinger, Stefan; Lang, Niklaus P; Zwahlen, Roger A

doi:10.1111/clr.12392

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Cai, W. X., Ma, L., Zheng, L. W., Kruse-Gujer, A., Stübinger, S., Lang, N. P., & Zwahlen, R. A. (2015). Influence of non-steroidal anti-inflammatory drugs (NSAIDs) on osseointegration of dental implants in rabbit calvaria. Clinical Oral Implants Research, 26(4), 478–483. https://doi.org/10.1111/clr.12392

Abstract

Aim: Until recently, adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs) on osseointegration of dental implants were unknown. Hence, this study investigated the short- and long-term effects of a 7-day regimen of parecoxib and diclofenac sodium on osseointegration of dental implants in calvarial bone. Material and methods: Eighteen New Zealand White rabbits were randomly allocated into three groups (each n = 6): Control group with no postoperative pain killers (Group A), diclofenac group (Group B) and parecoxib group (Gro