Publication: Pericytes stimulate oligodendrocyte progenitor cell differentiation during CNS remyelination
Pericytes stimulate oligodendrocyte progenitor cell differentiation during CNS remyelination
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De La Fuente, A. G., Lange, S., Silva, M. E., Gonzalez, G. A., Tempfer, H., van Wijngaarden, P., Zhao, C., Di Canio, L., Trost, A., Bieler, L., Zaunmair, P., Rotheneichner, P., O’Sullivan, A., Couillard-Despres, S., Errea, O., Mäe, M. A., Andrae, J., He, L., Keller, A., … Rivera, F. J. (2017). Pericytes stimulate oligodendrocyte progenitor cell differentiation during CNS remyelination. Cell Reports, 20(8), 1755–1764. https://doi.org/10.1016/j.celrep.2017.08.007
Abstract
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Abstract
The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close proximity to PCs. In Pdgfb(ret/ret) mice, which have reduced PC numbers, oligodendrocyte progenitor cell (OPC) differentiation was delayed, although remyelination proceeded to completion. PC-conditioned medium accelerated and
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Creators (Authors)
- De La Fuente, Alerie Guzman
- Lange, Simona
- Silva, Maria Elena
- Gonzalez, Ginez A
- Tempfer, Herbert
- van Wijngaarden, Peter
- Zhao, Chao
- Di Canio, Ludovica
- Trost, Andrea
- Bieler, Lara
- Zaunmair, Pia
- Rotheneichner, Peter
- O'Sullivan, Anna
- Couillard-Despres, Sebastien
- Errea, Oihana
- Mäe, Maarja A
- Andrae, Johanna
- He, Liqun
- Keller, Annika
- Bátiz, Luis F
- Betsholtz, Christer
- Aigner, Ludwig
- Franklin, Robin J M
- Rivera, Francisco J
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De La Fuente, A. G., Lange, S., Silva, M. E., Gonzalez, G. A., Tempfer, H., van Wijngaarden, P., Zhao, C., Di Canio, L., Trost, A., Bieler, L., Zaunmair, P., Rotheneichner, P., O’Sullivan, A., Couillard-Despres, S., Errea, O., Mäe, M. A., Andrae, J., He, L., Keller, A., … Rivera, F. J. (2017). Pericytes stimulate oligodendrocyte progenitor cell differentiation during CNS remyelination. Cell Reports, 20(8), 1755–1764. https://doi.org/10.1016/j.celrep.2017.08.007
