Rational Design of Degradation-Inducing Molecules

Abstract

Selective degradation of proteins by redirecting the living cell's inherent protein destruction mechanism represents a promising new therapeutic avenue, currently already being pursued in clinical settings. This strategy often employs bispecific molecules, capable of simultaneously interacting with target protein and components of the ubiquitin-proteasome system, eventually resulting in target ubiquitination and subsequent proteasomal degradation. By engaging in multiple rounds of target destruction, and thereby showing catalytic Show more