Publication: HIV-1 protease inhibition potential of functionalized polyoxometalates
HIV-1 protease inhibition potential of functionalized polyoxometalates
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Flütsch, A., Schroeder, T., Grütter, M. G., & Patzke, G. R. (2011). HIV-1 protease inhibition potential of functionalized polyoxometalates. Bioorganic & Medicinal Chemistry Letters, 21(4), 1162–1166. https://doi.org/10.1016/j.bmcl.2010.12.103
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Polyoxometalates (POMs) are interesting biomedical agents due to their versatile anticancer and antiviral properties, such as remarkable anti-HIV activity. Although POMs are tunable and easily accessible inorganic drug prototypes in principle, their full potential can only be tapped by enhancing their biocompatibility, for example, through organic functionalization. We have therefore investigated the HIV-1 protease inhibition potential of functionalized Keggin- and Dawson-type POMs with organic side chains. Their inhibitory performanc
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- Flütsch, A
- Schroeder, T
- Grütter, M G
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Flütsch, A., Schroeder, T., Grütter, M. G., & Patzke, G. R. (2011). HIV-1 protease inhibition potential of functionalized polyoxometalates. Bioorganic & Medicinal Chemistry Letters, 21(4), 1162–1166. https://doi.org/10.1016/j.bmcl.2010.12.103
