Publication: Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability
Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability
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Matamoros-Angles, A., Hervera, A., Soriano, J., Martí, E., Carulla, P., Llorens, F., Nuvolone, M., Aguzzi, A., Ferrer, I., Gruart, A., Delgado-García, J. M., & Del Río, J. A. (2022). Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability. BMC Biology, 20, 17. https://doi.org/10.1186/s12915-021-01203-0
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Background: Cellular prion protein (PrPC) is a cell surface GPI-anchored protein, usually known for its role in the pathogenesis of human and animal prionopathies. However, increasing knowledge about the participation of PrPC in prion pathogenesis contrasts with puzzling data regarding its natural physiological role. PrPC is expressed in a number of tissues, including at high levels in the nervous system, especially in neurons and glial cells, and while previous studies have established a neuroprotective role, conflicting evidence for
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- Matamoros-Angles, A
- Hervera, A
- Soriano, J
- Martí, E
- Carulla, P
- Llorens, F
- Nuvolone, M
- Ferrer, I
- Gruart, A
- Delgado-García, J M
- Del Río, J A
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Matamoros-Angles, A., Hervera, A., Soriano, J., Martí, E., Carulla, P., Llorens, F., Nuvolone, M., Aguzzi, A., Ferrer, I., Gruart, A., Delgado-García, J. M., & Del Río, J. A. (2022). Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability. BMC Biology, 20, 17. https://doi.org/10.1186/s12915-021-01203-0
