Publication: Candidate targets of copy number deletion events across 17 cancer types
Candidate targets of copy number deletion events across 17 cancer types
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Huang, Q., & Baudis, M. (2022). Candidate targets of copy number deletion events across 17 cancer types (No. 498080; BioRxiv). https://doi.org/10.1101/2022.06.29.498080
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Genome variation is the direct cause of cancer and driver of its clonal evolution. While the impact of many point mutations can be evaluated through their modification of individual genomic elements, even single copy number aberrations (CNAs) may encompass hundreds of genes and therefore pose challenges to untangle potentially complex functional effects. However, consistent, recurring and disease-specific patterns in the genome-wide CNA landscape imply that particular CNA may promote cancer type-specific characteristics. Discerning es
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Huang, Q., & Baudis, M. (2022). Candidate targets of copy number deletion events across 17 cancer types (No. 498080; BioRxiv). https://doi.org/10.1101/2022.06.29.498080
