Synthesis and performance of Acyloxy-diene-Fe(CO)(3) complexes with variable chain lengths as enzyme-triggered carbon monoxide-releasing molecules

Botov, Svetlana; Stamellou, Eleni; Romanski, Steffen; Guttentag, Miguel; Alberto, Roger; Neudoerfl, Joerg-Martin; Yard, Benito; Schmalz, Hans-Guenther

doi:10.1021/om301233h

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Botov, S., Stamellou, E., Romanski, S., Guttentag, M., Alberto, R., Neudoerfl, J.-M., Yard, B., & Schmalz, H.-G. (2013). Synthesis and performance of Acyloxy-diene-Fe(CO)(3) complexes with variable chain lengths as enzyme-triggered carbon monoxide-releasing molecules. Organometallics, 32(13), 3587–3594. https://doi.org/10.1021/om301233h

Abstract

Novel η4-acyloxy-cyclohexadiene-Fe(CO)3 complexes (with variable length of the acyloxy chain) were synthesized as potential enzyme-triggered carbon monoxide (CO)-releasing molecules (ET-CORMs). The molecular structure of two complexes was additionally confirmed by X-ray crystallography. The enzyme-triggered CO-releasing activity of the compounds was assessed under physiological conditions (37 °C, 0.1 M phosphate buffer, pH = 7.4) by headspace gas chromatography (GC) and additionally by means of a myoglobin assay (UV). The relative rat