Publication: RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP
RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP
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Budhathoki, J. B., Ray, S., Urban, V., Janscak, P., Yodh, J. G., & Balci, H. (2014). RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP. Nucleic Acids Research, 42, 11528–11545. https://doi.org/10.1093/nar/gku856
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Various helicases and single-stranded DNA (ssDNA) binding proteins are known to destabilize G-quadruplex (GQ) structures, which otherwise result in genomic instability. Bulk biochemical studies have shown that Bloom helicase (BLM) unfolds both intermolecular and intramolecular GQ in the presence of ATP. Using single molecule FRET, we show that binding of RecQ-core of BLM (will be referred to as BLM) to ssDNA in the vicinity of an intramolecular GQ leads to destabilization and unfolding of the GQ in the absence of ATP. We show that the
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- Budhathoki, Jagat B
- Ray, Sujay
- Urban, Vaclav
- Janscak, Pavel
- Yodh, Jaya G
- Balci, Hamza
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Budhathoki, J. B., Ray, S., Urban, V., Janscak, P., Yodh, J. G., & Balci, H. (2014). RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP. Nucleic Acids Research, 42, 11528–11545. https://doi.org/10.1093/nar/gku856
