Publication: Functionality, growth and accelerated aging of tissue engineered living autologous vascular grafts
Functionality, growth and accelerated aging of tissue engineered living autologous vascular grafts
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Kelm, J. M., Emmert, M. Y., Zürcher, A., Schmidt, D., Begus Nahrmann, Y., Rudolph, K. L., Weber, B., Brokopp, C. E., Frauenfelder, T., Leschka, S., Odermatt, B., Jenni, R., Falk, V., Zünd, G., & Hoerstrup, S. P. (2012). Functionality, growth and accelerated aging of tissue engineered living autologous vascular grafts. Biomaterials, 33, 8277–8285. https://doi.org/10.1016/j.biomaterials.2012.07.049
Abstract
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Living autologous tissue engineered vascular-grafts (TEVGs) with growth-capacity may overcome the limitations of contemporary artificial-prostheses. However, the multi-step invitro production of TEVGs requires extensive exvivo cell-manipulations with unknown effects on functionality and quality of TEVGs due to an accelerated biological age of the cells. Here, the impact of biological cell-age and tissue-remodeling capacity of TEVGs in relation to their clinical long-term functionality are investigated. TEVGs were implanted as pulmonar
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Creators (Authors)
- Kelm, Jens M
- Emmert, Maximilian Y
- Zürcher, Armin
- Schmidt, Dörthe
- Begus Nahrmann, Yvonne
- Rudolph, Karl L
- Weber, Benedikt
- Brokopp, Chad E
- Frauenfelder, Thomas
- Leschka, Sebastian
- Odermatt, Bernhard
- Jenni, Rolf
- Falk, Volkmar
- Zünd, Gregor
- Hoerstrup, Simon P
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Kelm, J. M., Emmert, M. Y., Zürcher, A., Schmidt, D., Begus Nahrmann, Y., Rudolph, K. L., Weber, B., Brokopp, C. E., Frauenfelder, T., Leschka, S., Odermatt, B., Jenni, R., Falk, V., Zünd, G., & Hoerstrup, S. P. (2012). Functionality, growth and accelerated aging of tissue engineered living autologous vascular grafts. Biomaterials, 33, 8277–8285. https://doi.org/10.1016/j.biomaterials.2012.07.049
