Publication: Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression
Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression
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Strekalova, T., Radford-Smith, D., Dunstan, I. K., Gorlova, A., Svirin, E., Sheveleva, E., Burova, A., Morozov, S., Lyundup, A., Berger, G., Anthony, D. C., & Walitza, S. (2024). Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression. Neurobiology of Stress, 31, 100646. https://doi.org/10.1016/j.ynstr.2024.100646
Abstract
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Introduction: Depression is increasingly diagnosed in adolescence, necessitating specific prevention and treatment methods. However, there is a lack of animal models mimicking juvenile depression. This study explores a novel model using ultrasound (US) stress in juvenile mice.
Methods: We employed the US stress model in one-month-old C57/BL6 mice, exposing them to alternating ultrasound frequencies (20-25 kHz and 25-45 kHz) for three weeks. These frequencies correspond to negative and neutral emotional states in rodents and can induc
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- Strekalova, Tatyana
- Radford-Smith, Daniel
- Dunstan, Isobel K
- Gorlova, Anna
- Svirin, Evgeniy
- Sheveleva, Elisaveta
- Burova, Alisa
- Morozov, Sergey
- Lyundup, Aleksey
- Berger, Gregor
- Anthony, Daniel C
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Strekalova, T., Radford-Smith, D., Dunstan, I. K., Gorlova, A., Svirin, E., Sheveleva, E., Burova, A., Morozov, S., Lyundup, A., Berger, G., Anthony, D. C., & Walitza, S. (2024). Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression. Neurobiology of Stress, 31, 100646. https://doi.org/10.1016/j.ynstr.2024.100646
