Publication: Fas activation in adipocytes impairs insulin-stimulated glucose uptake by reducing Akt
Fas activation in adipocytes impairs insulin-stimulated glucose uptake by reducing Akt
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Wueest, S., Rapold, R. A., Schoenle, E. J., & Konrad, D. (2010). Fas activation in adipocytes impairs insulin-stimulated glucose uptake by reducing Akt. FEBS Letters, 584, 4187–4192. https://doi.org/10.1016/j.febslet.2010.08.052
Abstract
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Fas (CD95) belongs to the superfamily of the tumor necrosis factor (TNF) receptors. Besides its key role in apoptosis, Fas contributes to non-apoptotic pathways such as cell proliferation and inflammation. In 3T3-L1 adipocytes, activation of Fas by Fas ligand decreased insulin-stimulated glucose uptake, without affecting cell viability. This decrease in glucose uptake was accompanied by reduced protein expression and diminished phosphorylation of Akt. Similarly, insulin-stimulated glucose incorporation and protein levels of Akt were i
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- Wueest, S
- Rapold, R A
- Schoenle, E J
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Wueest, S., Rapold, R. A., Schoenle, E. J., & Konrad, D. (2010). Fas activation in adipocytes impairs insulin-stimulated glucose uptake by reducing Akt. FEBS Letters, 584, 4187–4192. https://doi.org/10.1016/j.febslet.2010.08.052
