Publication: The C. elegans hox gene lin-39 controls cell cycle progression during vulval development
The C. elegans hox gene lin-39 controls cell cycle progression during vulval development
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Roiz, D., Escobar-Restrepo, J. M., Leu, P., & Hajnal, A. (2016). The C. elegans hox gene lin-39 controls cell cycle progression during vulval development. Developmental Biology, 418(1), 124–134. https://doi.org/10.1016/j.ydbio.2016.07.018
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Cell fate specification during organogenesis is usually followed by a phase of cell proliferation to produce the required number of differentiated cells. The Caenorhabditis elegans vulva is an excellent model to study how cell fate specification and cell proliferation are coordinated. The six vulval precursor cells (VPCs) are born at the first larval stage, but they arrest in the G1 phase of the cell cycle until the beginning of the third larval stage, when their fates are specified and the three proximal VPCs proliferate to generate
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Roiz, D., Escobar-Restrepo, J. M., Leu, P., & Hajnal, A. (2016). The C. elegans hox gene lin-39 controls cell cycle progression during vulval development. Developmental Biology, 418(1), 124–134. https://doi.org/10.1016/j.ydbio.2016.07.018