Publication: Characterization of HIF-1 alpha overexpressing HeLa cells and implications for gene therapy.
Characterization of HIF-1 alpha overexpressing HeLa cells and implications for gene therapy.
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Hofer, T., Desbaillets, I., Höpfl, G. R., Wenger, R. H., & Gassmann, M. (2002). Characterization of HIF-1 alpha overexpressing HeLa cells and implications for gene therapy. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp, 133, 475–481. https://doi.org/10.1016/S1532-0456(02)00117-5
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Upon exposing mammalian tissues to hypoxia, expression of a number of physiologically important genes such as erythropoietin and vascular endothelial growth factor (VEGF) increases. The key regulator for this oxygen-dependent gene expression is the hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor consisting of an alpha and a beta subunit. Both HIF-1 subunits are widely expressed in the cells and tissue of vertebrates, flies, fishes, worms and probably most other species. The beta subunit (also termed ARNT, aryl
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- Hofer, T
- Desbaillets, I
- Wenger, R H
- Gassmann, M
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Hofer, T., Desbaillets, I., Höpfl, G. R., Wenger, R. H., & Gassmann, M. (2002). Characterization of HIF-1 alpha overexpressing HeLa cells and implications for gene therapy. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp, 133, 475–481. https://doi.org/10.1016/S1532-0456(02)00117-5
