Publication: The positive allosteric GABAB receptor modulator rac-BHFF enhances baclofen-mediated analgesia in neuropathic mice.
The positive allosteric GABAB receptor modulator rac-BHFF enhances baclofen-mediated analgesia in neuropathic mice.
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Zemoura, K., Ralvenius, W. T., Malherbe, P., & Benke, D. (2016). The positive allosteric GABAB receptor modulator rac-BHFF enhances baclofen-mediated analgesia in neuropathic mice. Neuropharmacology, 108, 172–178. https://doi.org/10.1016/j.neuropharm.2016.04.028
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Neuropathic pain is associated with impaired inhibitory control of spinal dorsal horn neurons, which are involved in processing pain signals. The metabotropic GABAB receptor is an important component of the inhibitory system and is highly expressed in primary nociceptors and intrinsic dorsal horn neurons to control their excitability. Activation of GABAB receptors with the orthosteric agonist baclofen effectively reliefs neuropathic pain but is associated with severe side effects that prevent its widespread application. The recently d
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- Zemoura, Khaled
- Ralvenius, William T
- Malherbe, Pari
- Benke, Dietmar
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Zemoura, K., Ralvenius, W. T., Malherbe, P., & Benke, D. (2016). The positive allosteric GABAB receptor modulator rac-BHFF enhances baclofen-mediated analgesia in neuropathic mice. Neuropharmacology, 108, 172–178. https://doi.org/10.1016/j.neuropharm.2016.04.028
