Publication: Dpp spreading is required for medial but not for lateral wing disc growth
Dpp spreading is required for medial but not for lateral wing disc growth
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Harmansa, S., Hamaratoglu, F., Affolter, M., & Caussinus, E. (2015). Dpp spreading is required for medial but not for lateral wing disc growth. Nature, 527(7578), 317–227. https://doi.org/10.1038/nature15712
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Drosophila Decapentaplegic (Dpp) has served as a paradigm to study morphogen-dependent growth control. However, the role of a Dpp gradient in tissue growth remains highly controversial. Two fundamentally different models have been proposed: the 'temporal rule' model suggests that all cells of the wing imaginal disc divide upon a 50% increase in Dpp signalling, whereas the 'growth equalization model' suggests that Dpp is only essential for proliferation control of the central cells. Here, to discriminate between these two models, we ge
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Harmansa, S., Hamaratoglu, F., Affolter, M., & Caussinus, E. (2015). Dpp spreading is required for medial but not for lateral wing disc growth. Nature, 527(7578), 317–227. https://doi.org/10.1038/nature15712