Publication: Glycine receptors and glycine transporters: targets for novel analgesics?
Glycine receptors and glycine transporters: targets for novel analgesics?
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Zeilhofer, H. U., Acuña, M. A., Gingras, J., & Yévenes, G. E. (2018). Glycine receptors and glycine transporters: targets for novel analgesics? Cellular and Molecular Life Sciences, 75(3), 447–465. https://doi.org/10.1007/s00018-017-2622-x
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Glycinergic neurotransmission has long been known for its role in spinal motor control. During the last two decades, additional functions have become increasingly recognized-among them is a critical contribution to spinal pain processing. Studies in rodent pain models provide proof-of-concept evidence that enhancing inhibitory glycinergic neurotransmission reduces chronic pain symptoms. Apparent strategies for pharmacological intervention include positive allosteric modulators of glycine receptors and modulators or inhibitors of the g
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Creators (Authors)
- Acuña, Mario A
- Gingras, Jacinthe
- Yévenes, Gonzalo E
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Citations
Zeilhofer, H. U., Acuña, M. A., Gingras, J., & Yévenes, G. E. (2018). Glycine receptors and glycine transporters: targets for novel analgesics? Cellular and Molecular Life Sciences, 75(3), 447–465. https://doi.org/10.1007/s00018-017-2622-x
