Publication: G-quadruplexes as potential therapeutic targets for embryonal tumors
G-quadruplexes as potential therapeutic targets for embryonal tumors
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Shalaby, T., Fiaschetti, G., Nagasawa, K., Shin-Ya, K., Baumgartner, M., & Grotzer, M. (2013). G-quadruplexes as potential therapeutic targets for embryonal tumors. Molecules, 18(10), 12500–12537. https://doi.org/10.3390/molecules181012500
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Abstract
Embryonal tumors include a heterogeneous group of highly malignant neoplasms that primarily affect infants and children and are characterized by a high rate of mortality and treatment-related morbidity, hence improved therapies are clearly needed. G-quadruplexes are special secondary structures adopted in guanine (G)-rich DNA sequences that are often present in biologically important regions, e.g. at the end of telomeres and in the regulatory regions of oncogenes such as MYC. Owing to the significant roles that both telomeres and MYC
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- Shalaby, Tarek
- Fiaschetti, Giulio
- Nagasawa, Kazuo
- Shin-Ya, Kazuo
- Baumgartner, Martin
- Grotzer, Michael
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Shalaby, T., Fiaschetti, G., Nagasawa, K., Shin-Ya, K., Baumgartner, M., & Grotzer, M. (2013). G-quadruplexes as potential therapeutic targets for embryonal tumors. Molecules, 18(10), 12500–12537. https://doi.org/10.3390/molecules181012500
