Publication: Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
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Peyssonnaux, C., Zinkernagel, A. S., Schuepbach, R. A., Rankin, E., Vaulont, S., Haase, V. H., Nizet, V., & Johnson, R. S. (2007). Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). Journal of Clinical Investigation, 117(7), 1926–1932. https://doi.org/10.1172/JCI31370
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Abstract
Iron is essential for many biological processes, including oxygen delivery, and its supply is tightly regulated. Hepcidin, a small peptide synthesized in the liver, is a key regulator of iron absorption and homeostasis in mammals. Hepcidin production is increased by iron overload and decreased by anemia and hypoxia; but the molecular mechanisms that govern the hepcidin response to these stimuli are not known. Here we establish that the von Hippel-Lindau/hypoxia-inducible transcription factor (VHL/HIF) pathway is an essential link betw
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- Peyssonnaux, Carole
- Zinkernagel, Annelies S
- Schuepbach, Reto A
- Rankin, Erinn
- Vaulont, Sophie
- Haase, Volker H
- Nizet, Victor
- Johnson, Randall S
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Peyssonnaux, C., Zinkernagel, A. S., Schuepbach, R. A., Rankin, E., Vaulont, S., Haase, V. H., Nizet, V., & Johnson, R. S. (2007). Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). Journal of Clinical Investigation, 117(7), 1926–1932. https://doi.org/10.1172/JCI31370
