Publication: Effect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats
Effect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats
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Tarasco, E., Seebeck, P., Pfundstein, S., Daly, A. F., Eugster, P. J., Harris, A. G., Grouzmann, E., Lutz, T. A., & Boyle, C. N. (2017). Effect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats. Endocrine, 58(1), 124–133. https://doi.org/10.1007/s12020-017-1386-2
Abstract
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PURPOSE: Somatostatin analogs are widely used to treat conditions associated with hormonal hypersecretion such as acromegaly and metastatic neuroendocrine tumors. First generation somatostatin analogs, such as octreotide and lanreotide, have high affinity for somatostatin receptor subtype 2 (SSTR2), but have incomplete efficacy in many patients. Pasireotide targets multiple SSTRs, having the highest affinity for SSTR5, but causes hyperglycemia and diabetes mellitus in preclinical and clinical studies. AP102 is a new somatostatin analo
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- Tarasco, Erika
- Seebeck, Petra
- Pfundstein, Svende
- Daly, Adrian F
- Eugster, Philippe J
- Harris, Alan G
- Grouzmann, Eric
- Lutz, Thomas A
- Boyle, Christina N
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Tarasco, E., Seebeck, P., Pfundstein, S., Daly, A. F., Eugster, P. J., Harris, A. G., Grouzmann, E., Lutz, T. A., & Boyle, C. N. (2017). Effect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats. Endocrine, 58(1), 124–133. https://doi.org/10.1007/s12020-017-1386-2
