Publication: Evaluation of substituted 1,2,3-Dithiazoles as inhibitors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein via a proposed zinc ejection mechanism.
Evaluation of substituted 1,2,3-Dithiazoles as inhibitors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein via a proposed zinc ejection mechanism.
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Asquith, C. R. M., Konstantinova, L. S., Laitinen, T., Meli, M. L., Poso, A., Rakitin, O. A., Hofmann-Lehmann, R., & Hilton, S. T. (2016). Evaluation of substituted 1,2,3-Dithiazoles as inhibitors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein via a proposed zinc ejection mechanism. ChemMedChem, 11, 2119–2126. https://doi.org/10.1002/cmdc.201600260
Abstract
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A diverse library of 5-thieno-, 5-oxo-, and 5-imino-1,2,3-dithiazole derivatives was synthesized and evaluated for efficacy against the feline immunodeficiency virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.
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Creators (Authors)
- Asquith, Christopher R M
- Konstantinova, Lidia S
- Laitinen, Tuomo
- Meli, Marina L
- Poso, Antti
- Rakitin, Oleg A
- Hilton, Stephen T
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Citations
Asquith, C. R. M., Konstantinova, L. S., Laitinen, T., Meli, M. L., Poso, A., Rakitin, O. A., Hofmann-Lehmann, R., & Hilton, S. T. (2016). Evaluation of substituted 1,2,3-Dithiazoles as inhibitors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein via a proposed zinc ejection mechanism. ChemMedChem, 11, 2119–2126. https://doi.org/10.1002/cmdc.201600260
