Sleep spindles across youth affected by schizophrenia or anti-N-methyl-D-aspartate-receptor encephalitis

Dimitriades, Maria E; Markovic, Andjela; Gefferie, Silvano R; Buckley, Ashura; Driver, David I; Rapoport, Judith L; Nosadini, Margherita; Rostasy, Kevin; Sartori, Stefano; Suppiej, Agnese; Kurth, Salome; Franscini, Maurizia; Walitza, Susanne; Huber, Reto; Tarokh, Leila; Bölsterli, Bigna K; Gerstenberg, Miriam

doi:10.5167/uzh-234716

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Dimitriades, M. E., Markovic, A., Gefferie, S. R., Buckley, A., Driver, D. I., Rapoport, J. L., Nosadini, M., Rostasy, K., Sartori, S., Suppiej, A., Kurth, S., Franscini, M., Walitza, S., Huber, R., Tarokh, L., Bölsterli, B. K., & Gerstenberg, M. (2023). Sleep spindles across youth affected by schizophrenia or anti-N-methyl-D-aspartate-receptor encephalitis. Frontiers in Psychiatry, 14, 1055459. https://doi.org/10.3389/fpsyt.2023.1055459

Abstract

BackgroundSleep disturbances are intertwined with the progression and pathophysiology of psychotic symptoms in schizophrenia. Reductions in sleep spindles, a major electrophysiological oscillation during non-rapid eye movement sleep, have been identified in patients with schizophrenia as a potential biomarker representing the impaired integrity of the thalamocortical network. Altered glutamatergic neurotransmission within this network via a hypofunction of the N-methyl-D-aspartate receptor (NMDAR) is one of the hypotheses at the heart