Publication: TBX3 acts as tissue-specific component of the Wnt/β-catenin enhanceosome
TBX3 acts as tissue-specific component of the Wnt/β-catenin enhanceosome
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Zimmerli, D., Borrelli, C., Jauregi-Miguel, A., Söderholm, S., Brütsch, S., Doumpas, N., Reichmuth, J., Murphy-Seiler, F., Aguet, M., Basler, K., Moor, A. E., & Cantù, C. (2020). TBX3 acts as tissue-specific component of the Wnt/β-catenin enhanceosome (No. 053561; BioRxiv). https://doi.org/10.1101/2020.04.22.053561
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BCL9 and PYGO are β-catenin cofactors that enhance the transcription of Wnt target genes. They have been proposed as therapeutic targets to diminish Wnt signalling output in intestinal malignancies. Here we find that, in colorectal cancer cells and in developing mouse forelimbs, BCL9 proteins sustain the action of β-catenin in a largely PYGO-independent manner. Our genetic analyses implied that BCL9 necessitates other interaction partners in mediating its transcriptional output. We identified the transcription factor TBX3 as a candida
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Zimmerli, D., Borrelli, C., Jauregi-Miguel, A., Söderholm, S., Brütsch, S., Doumpas, N., Reichmuth, J., Murphy-Seiler, F., Aguet, M., Basler, K., Moor, A. E., & Cantù, C. (2020). TBX3 acts as tissue-specific component of the Wnt/β-catenin enhanceosome (No. 053561; BioRxiv). https://doi.org/10.1101/2020.04.22.053561
