Beta lactamase-producing Neisseria gonorrhoeae alleviates Amoxicillin-induced chlamydial persistence in a novel in vitro co-infection model

Onorini, Delia; Schoborg, Robert; Borel, Nicole; Leonard, Cory

doi:10.1016/j.crmicr.2023.100188

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Onorini, D., Schoborg, R., Borel, N., & Leonard, C. (2023). Beta lactamase-producing Neisseria gonorrhoeae alleviates Amoxicillin-induced chlamydial persistence in a novel in vitro co-infection model. Current Research in Microbial Sciences, 4, 100188. https://doi.org/10.1016/j.crmicr.2023.100188

Abstract

Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) cause most bacterial sexually transmitted infections (STIs) worldwide. Epidemiological studies have shown high percentages of co-infections with CT/NG and indicate that NG co-infection can reactivate CT shedding during persistent chlamydial infection. These data also suggest that biological interaction between the two bacteria may increase susceptibility or transmissibility. CT is an obligate intracellular bacterium with a developmental cycle that alternates between two forms: