Publication: Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling
Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling
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Germano, S., Barberis, D., Santoro, M. M., Penengo, L., Citri, A., Yarden, Y., & Gaudino, G. (2006). Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling. Journal of Biological Chemistry, 281, 21710–21719. https://doi.org/10.1074/jbc.M602014200
Abstract
Abstract
Abstract
Ron, the tyrosine kinase receptor for macrophage-stimulating protein is responsible for proliferation and migration of cells from different tissues. Ron can acquire oncogenic potential by single point mutations in the kinase domain, and dysregulated Ron signaling has been involved in the development of different human cancers. We have previously shown that ligand-activated Ron recruits the negative regulator c-Cbl, which mediates its ubiquitylation and degradation. Here we report that Ron is ubiquitylated also by the U-box E3 ligase C
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Creators (Authors)
- Germano, Serena
- Barberis, Davide
- Santoro, Massimo M
- Penengo, Lorenza
- Citri, Ami
- Yarden, Yosef
- Gaudino, Giovanni
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Citations
Germano, S., Barberis, D., Santoro, M. M., Penengo, L., Citri, A., Yarden, Y., & Gaudino, G. (2006). Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling. Journal of Biological Chemistry, 281, 21710–21719. https://doi.org/10.1074/jbc.M602014200
