Publication: Inhibition of meningitis-associated neutrophil apoptosis by TNF- depends on functional PI3-kinase in monocytes
Inhibition of meningitis-associated neutrophil apoptosis by TNF- depends on functional PI3-kinase in monocytes
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Recher, M., Malipiero, U., Schaer, D. J., Koedel, U., Pfister, H. W., Birchler, T., Petrausch, U., Claus, H., Gast, H., & Fontana, A. (2013). Inhibition of meningitis-associated neutrophil apoptosis by TNF- depends on functional PI3-kinase in monocytes. Journal of Leukocyte Biology, 93(2), 259–266. https://doi.org/10.1189/jlb.0511218
Abstract
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Abstract
In bacterial meningitis, neutrophils cope with bacterial infection but also lead to tissue damage. The balance of beneficial and harmful effects may depend on the lifespan of the neutrophils in the CNS. Here, we show that CSF of patients with meningococcal meningitis contains a neutrophil apoptosis-inhibiting capacity that correlates with TNF-α content. In vitro experiments show that Neisseria meningitidis as well as LPS derived from these bacteria regulated neutrophil apoptosis mainly by stimulating TNF-α production in monocytes. Whe
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- Recher, M
- Malipiero, U
- Schaer, D J
- Koedel, U
- Pfister, H W
- Birchler, T
- Petrausch, U
- Claus, H
- Gast, H
- Fontana, A
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Recher, M., Malipiero, U., Schaer, D. J., Koedel, U., Pfister, H. W., Birchler, T., Petrausch, U., Claus, H., Gast, H., & Fontana, A. (2013). Inhibition of meningitis-associated neutrophil apoptosis by TNF- depends on functional PI3-kinase in monocytes. Journal of Leukocyte Biology, 93(2), 259–266. https://doi.org/10.1189/jlb.0511218
