Immunomodulatory effects of 25-hydroxyvitamin D3 on monocytic cell differentiation and influence of vitamin D3 polymorphisms in type 1 diabetes

Mauf, Sabrina; Penna-Martinez, Marissa; Jentzsch, Thorsten; Ackermann, Hanns; Henrich, Dirk; Radeke, Heinfried H; Brück, Patrick; Badenhoop, Klaus; Ramos-Lopez, Elizabeth

doi:10.1016/j.jsbmb.2014.11.001

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Mauf, S., Penna-Martinez, M., Jentzsch, T., Ackermann, H., Henrich, D., Radeke, H. H., Brück, P., Badenhoop, K., & Ramos-Lopez, E. (2015). Immunomodulatory effects of 25-hydroxyvitamin D3 on monocytic cell differentiation and influence of vitamin D3 polymorphisms in type 1 diabetes. Journal of Steroid Biochemistry and Molecular Biology, 147, 17–23. https://doi.org/10.1016/j.jsbmb.2014.11.001

Abstract

BACKGROUND

Preventive measures and a causal therapy for type 1 diabetes (T1D) remain elusive. An imbalance between different dendritic cells (DC) with increased immunogenic DC and decreased tolerogenic DC (tDC) may lead to T1D. Furthermore, 25(OH)D3 is associated with less adverse effects than 1,25(OH)2D3.

PURPOSE

The present study was performed to clarify the remaining issues about the cellular effects of 25(OH)D3 in patients with T1D and the role of genetic polymorphisms of the vitamin D3 (VD3) metabolism on a functional cellular