Publication: A rat model of Parkinsonism shows depletion of dopamine in the retina.
A rat model of Parkinsonism shows depletion of dopamine in the retina.
Date
Date
Date
Citations
Biehlmaier, O., Alam, M., & Schmidt, W. J. (2007). A rat model of Parkinsonism shows depletion of dopamine in the retina. Neurochemistry International, 50(1), 189–195. https://doi.org/10.1016/j.neuint.2006.08.001
Abstract
Abstract
Abstract
The retinal dopamine (DA) deficiency is an important feature of the pathogenesis in Parkinson's disease (PD) visual dysfunction. Systemic inhibition of complex I (rotenone) in rats has been proposed as a model of PD. In this study, we investigated whether systemic inhibition of complex I can induce impairment of DA-ergic cells in the retina, similar to the destruction of retinal cells found in PD patients. Rotenone (2.5mg/kg i.p., daily) was administered over 60 days. Neurochemically, rotenone treated rats showed a depletion of DA in
Additional indexing
Creators (Authors)
- Biehlmaier, O
- Alam, M
- Schmidt, W J
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Keywords
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Publisher DOI
Citations
Biehlmaier, O., Alam, M., & Schmidt, W. J. (2007). A rat model of Parkinsonism shows depletion of dopamine in the retina. Neurochemistry International, 50(1), 189–195. https://doi.org/10.1016/j.neuint.2006.08.001
