Publication: Cardioprotection by cardiac progenitor cell-secreted exosomes: role of pregnancy-associated plasma protein-A
Cardioprotection by cardiac progenitor cell-secreted exosomes: role of pregnancy-associated plasma protein-A
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Barile, L., Cervio, E., Lionetti, V., Milano, G., Ciullo, A., Biemmi, V., Bolis, S., Altomare, C., Matteucci, M., Di Silvestre, D., Brambilla, F., Fertig, T. E., Torre, T., Demertzis, S., Mauri, P., Moccetti, T., & Vassalli, G. (2018). Cardioprotection by cardiac progenitor cell-secreted exosomes: role of pregnancy-associated plasma protein-A. Cardiovascular Research, 114(7), 992–1005. https://doi.org/10.1093/cvr/cvy055
Abstract
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Abstract
Aims ell therapy trials using cardiac-resident progenitor cells (CPCs) and bone marrow-derived mesenchymal stem/progenitor cells (BMCs) in patients after myocardial infarction have provided encouraging results. Exosomes, nanosized extracellular vesicles of endosomal origin, figure prominently in the bioactivities of these cells. However, a head-to-head comparison of exosomes from the two cell types has not been performed yet. Methods and results PCs and BMCs were derived from cardiac atrial appendage specimens and sternal bone marrow,
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- Barile, Lucio
- Cervio, Elisabetta
- Lionetti, Vincenzo
- Milano, Giuseppina
- Ciullo, Alessandra
- Biemmi, Vanessa
- Bolis, Sara
- Altomare, Claudia
- Matteucci, Marco
- Di Silvestre, Dario
- Brambilla, Francesca
- Fertig, Tudor Emanuel
- Torre, Tiziano
- Demertzis, Stefanos
- Mauri, Pierluigi
- Moccetti, Tiziano
- Vassalli, Giuseppe
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Barile, L., Cervio, E., Lionetti, V., Milano, G., Ciullo, A., Biemmi, V., Bolis, S., Altomare, C., Matteucci, M., Di Silvestre, D., Brambilla, F., Fertig, T. E., Torre, T., Demertzis, S., Mauri, P., Moccetti, T., & Vassalli, G. (2018). Cardioprotection by cardiac progenitor cell-secreted exosomes: role of pregnancy-associated plasma protein-A. Cardiovascular Research, 114(7), 992–1005. https://doi.org/10.1093/cvr/cvy055
