Publication: Reverse engineering of the pattern recognition receptor FLS2 reveals key design principles of broader recognition spectra against evading flg22 epitopes
Reverse engineering of the pattern recognition receptor FLS2 reveals key design principles of broader recognition spectra against evading flg22 epitopes
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Zhang, S., Liu, S., Lai, H.-F., Bender, K. W., Kim, G., Caflisch, A., & Zipfel, C. (2025). Reverse engineering of the pattern recognition receptor FLS2 reveals key design principles of broader recognition spectra against evading flg22 epitopes. Nature Plants, 11(8), 1642–1657. https://doi.org/10.1038/s41477-025-02050-5
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In the ongoing plant-pathogen arms race, plants use pattern recognition receptors (PRRs) to recognize pathogen-associated molecular patterns (PAMPs), while in successful pathogens, PAMPs can evolve to evade detection. Engineering PRRs to recognize evading PAMPs could potentially generate broad-spectrum and durable disease resistance. Here we reverse-engineered two natural variants of the PRR FLAGELLIN SENSING 2 (FLS2), VrFLS2XL and GmFLS2b, with extended recognition specificities towards evading flg22 variants. We identified minimal g
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Zhang, S., Liu, S., Lai, H.-F., Bender, K. W., Kim, G., Caflisch, A., & Zipfel, C. (2025). Reverse engineering of the pattern recognition receptor FLS2 reveals key design principles of broader recognition spectra against evading flg22 epitopes. Nature Plants, 11(8), 1642–1657. https://doi.org/10.1038/s41477-025-02050-5
