Improved Generation of Induced Pluripotent Stem Cells From Hair Derived Keratinocytes - A Tool to Study Neurodevelopmental Disorders as ADHD

Re, Silvano; Dogan, Asli Aybike; Ben-Shachar, Dorit; Berger, Gregor; Werling, Anna Maria; Walitza, Susanne; Grünblatt, Edna

doi:10.3389/fncel.2018.00321

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Re, S., Dogan, A. A., Ben-Shachar, D., Berger, G., Werling, A. M., Walitza, S., & Grünblatt, E. (2018). Improved Generation of Induced Pluripotent Stem Cells From Hair Derived Keratinocytes - A Tool to Study Neurodevelopmental Disorders as ADHD. Frontiers in Cellular Neuroscience, 12, 321. https://doi.org/10.3389/fncel.2018.00321

Abstract

In the last decade, there is an increasing application of induced pluripotent stem cells (iPSCs) for disease modeling. The iPSC technology enables the study of patient-specific neuronal cell lines to evaluate dysfunction at the cellular level and identify the responsible genetic factors. This approach might be particularly valuable for filling the gap of knowledge at the cellular and molecular levels underlying the pathophysiology of various neurodevelopmental and/or psychiatric disorders, such as attention-deficit hyperactivity diso