Publication: High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification
High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification
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Zhu, Y., Weiss, T., Zhang, Q., Sun, R., et al, Gillet, L., & Weller, M. (2019). High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification. Molecular Oncology, 13(11), 2305–2328. https://doi.org/10.1002/1878-0261.12570
Abstract
Abstract
Abstract
Formalin-fixed, paraffin-embedded (FFPE), biobanked tissue samples offer an invaluable resource for clinical and biomarker research. Here, we developed a pressure cycling technology (PCT)-SWATH mass spectrometry workflow to analyze FFPE tissue proteomes and applied it to the stratification of prostate cancer (PCa) and diffuse large B-cell lymphoma (DLBCL) samples. We show that the proteome patterns of FFPE PCa tissue samples and their analogous fresh-frozen (FF) counterparts have a high degree of similarity and we confirmed multiple p
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Creators (Authors)
- Zhu, Yi
- Weiss, Tobias
- Zhang, Qiushi
- Sun, Rui
- Gillet, Ludovic
- Weller, Michael
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Citations
Zhu, Y., Weiss, T., Zhang, Q., Sun, R., et al, Gillet, L., & Weller, M. (2019). High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification. Molecular Oncology, 13(11), 2305–2328. https://doi.org/10.1002/1878-0261.12570
