Publication: Titanium induced production of chemokines CCL17/TARC and CCL22/MDC in human osteoclasts and osteoblasts
Titanium induced production of chemokines CCL17/TARC and CCL22/MDC in human osteoclasts and osteoblasts
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Cadosch, D., Gautschi, O. P., Chan, E., Simmen, H. P., & Filgueira, L. (2010). Titanium induced production of chemokines CCL17/TARC and CCL22/MDC in human osteoclasts and osteoblasts. Journal of Biomedical Materials Research. Part A, 92(2), 475–483. https://doi.org/10.1002/jbm.a.32390
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There is increasing evidence that titanium (Ti(IV)) ions are released from orthopedic implants and play a role in aseptic loosening. This study aimed to investigate whether titanium induces expression of chemokines and cytokines that are important in osteoclastogenesis in human osteoclasts and osteoblasts. Incubation of those cells with 1 M Ti(IV) significantly upregulated expression of CCL17/TARC and CCL22/MDC, RANK-L, M-CSF and pro-inflammatory cytokines as determined by quantitative real-time PCR and ELISA assays. Additionally, flo
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- Cadosch, D
- Gautschi, O P
- Chan, E
- Simmen, H P
- Filgueira, L
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Cadosch, D., Gautschi, O. P., Chan, E., Simmen, H. P., & Filgueira, L. (2010). Titanium induced production of chemokines CCL17/TARC and CCL22/MDC in human osteoclasts and osteoblasts. Journal of Biomedical Materials Research. Part A, 92(2), 475–483. https://doi.org/10.1002/jbm.a.32390