Publication: Glucocorticoid receptor gene variants and lower expression of NR3C1 are associated with cocaine use
Glucocorticoid receptor gene variants and lower expression of NR3C1 are associated with cocaine use
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Schote, A. B., Jäger, K., Kroll, S. L., Vonmoos, M., Hulka, L. M., Preller, K. H., Meyer, J., Grünblatt, E., & Quednow, B. B. (2019). Glucocorticoid receptor gene variants and lower expression of NR3C1 are associated with cocaine use. Addiction Biology, 24(4), 730–742. https://doi.org/10.1111/adb.12632
Abstract
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Abstract
Animal and cross-sectional human studies suggest that chronic cocaine use is associated with altered responsivity of the hypothalamic-pituitary-adrenal axis to stress. Moreover, increased susceptibility to stress has been proposed as an important factor for development, maintenance and relapse of cocaine addiction. As the glucocorticoid receptor gene (NR3C1) mediates genomic effects of the stress hormone cortisol, we investigated NR3C1 expression and the association of NR3C1 genotypes with cocaine use, addiction and comorbid psychiatr
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Creators (Authors)
- Schote, Andrea B
- Jäger, Kristina
- Kroll, Sara L
- Vonmoos, Matthias
- Hulka, Lea M
- Preller, Katrin H
- Meyer, Jobst
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Citations
Schote, A. B., Jäger, K., Kroll, S. L., Vonmoos, M., Hulka, L. M., Preller, K. H., Meyer, J., Grünblatt, E., & Quednow, B. B. (2019). Glucocorticoid receptor gene variants and lower expression of NR3C1 are associated with cocaine use. Addiction Biology, 24(4), 730–742. https://doi.org/10.1111/adb.12632
