Publication: Novel Organism Verification and Analysis (NOVA) study: identification of 35 clinical isolates representing potentially novel bacterial taxa using a pipeline based on whole genome sequencing
Novel Organism Verification and Analysis (NOVA) study: identification of 35 clinical isolates representing potentially novel bacterial taxa using a pipeline based on whole genome sequencing
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Muigg, V., Seth-Smith, H. M. B., Adam, K.-M., Weisser, M., Hinic, V., Blaich, A., Roloff, T., Heininger, U., Schmid, H., Kohler, M., Graf, L., Winterflood, D. M., Schlaepfer, P., & Goldenberger, D. (2024). Novel Organism Verification and Analysis (NOVA) study: identification of 35 clinical isolates representing potentially novel bacterial taxa using a pipeline based on whole genome sequencing. BMC Microbiology, 24(1), 14. https://doi.org/10.1186/s12866-023-03163-7
Abstract
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Abstract
BACKGROUND Reliable species identification of cultured isolates is essential in clinical bacteriology. We established a new study algorithm named NOVA - Novel Organism Verification and Analysis to systematically analyze bacterial isolates that cannot be characterized by conventional identification procedures MALDI-TOF MS and partial 16 S rRNA gene sequencing using Whole Genome Sequencing (WGS).
RESULTS We identified a total of 35 bacterial strains that represent potentially novel species. Corynebacterium sp. (n = 6) and Schaalia sp.
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- Muigg, Veronika
- Seth-Smith, Helena M B
- Adam, Kai-Manuel
- Weisser, Maja
- Hinic, Vladimira
- Blaich, Annette
- Roloff, Tim
- Heininger, Ulrich
- Schmid, Hanna
- Kohler, Maurus
- Graf, Lukas
- Winterflood, Dylan M
- Schlaepfer, Pascal
- Goldenberger, Daniel
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Muigg, V., Seth-Smith, H. M. B., Adam, K.-M., Weisser, M., Hinic, V., Blaich, A., Roloff, T., Heininger, U., Schmid, H., Kohler, M., Graf, L., Winterflood, D. M., Schlaepfer, P., & Goldenberger, D. (2024). Novel Organism Verification and Analysis (NOVA) study: identification of 35 clinical isolates representing potentially novel bacterial taxa using a pipeline based on whole genome sequencing. BMC Microbiology, 24(1), 14. https://doi.org/10.1186/s12866-023-03163-7
