Publication: Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model
Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model
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Michailidou, C., Jones, M., Walker, P., Kamarashev, J., Kelly, A., & Hurlstone, A. F. L. (2009). Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model. Disease Models & Mechanisms, 2, 399–411. https://doi.org/10.1242/dmm.001149
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Abstract
Deregulated Ras signalling is implicated in most human neoplasia, exemplified by melanoma. Whereas Raf activation occurs almost ubiquitously in benign and malignant melanocytic neoplasms, implying an involvement in tumour initiation, phosphoinositide 3-kinase (PI3K) activation occurs predominantly in malignant neoplasms, implying an involvement in malignant progression. Here, we dissect the contributions of these two pathways to tumourigenesis in vivo, by modulating their activities in zebrafish melanocytes. Misexpression of oncogenic
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- Michailidou, C
- Jones, M
- Walker, P
- Kamarashev, J
- Kelly, A
- Hurlstone, A F L
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Michailidou, C., Jones, M., Walker, P., Kamarashev, J., Kelly, A., & Hurlstone, A. F. L. (2009). Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model. Disease Models & Mechanisms, 2, 399–411. https://doi.org/10.1242/dmm.001149
