Publication: Serotype chimeric oncolytic adenovirus coding for GM-CSF for treatment of sarcoma in rodents and humans
Serotype chimeric oncolytic adenovirus coding for GM-CSF for treatment of sarcoma in rodents and humans
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Bramante, S., Koski, A., Kipar, A., Diaconu, I., Liikanen, I., Hemminki, O., Vassilev, L., Parviainen, S., Cerullo, V., Pesonen, S. K., Oksanen, M., Heiskanen, R., Rouvinen-Lagerström, N., Merisalo-Soikkeli, M., Hakonen, T., Joensuu, T., Kanerva, A., Pesonen, S., & Hemminki, A. (2014). Serotype chimeric oncolytic adenovirus coding for GM-CSF for treatment of sarcoma in rodents and humans. International Journal of Cancer, 135, 720–730. https://doi.org/10.1002/ijc.28696
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Abstract
Sarcomas are a relatively rare cancer, but often incurable at the late metastatic stage. Oncolytic immunotherapy has gained attention over the past years, and a wide range of oncolytic viruses have been delivered via intratumoral injection with positive safety and promising efficacy data. Here, we report preclinical and clinical results from treatment of sarcoma with oncolytic adenovirus Ad5/3-D24-GMCSF (CGTG-102). Ad5/3-D24-GMCSF is a serotype chimeric oncolytic adenovirus coding for human granulocyte-macrophage colony-stimulating fa
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Creators (Authors)
- Bramante, S
- Koski, A
- Kipar, A
- Diaconu, I
- Liikanen, I
- Hemminki, O
- Vassilev, L
- Parviainen, S
- Cerullo, V
- Pesonen, S K
- Oksanen, M
- Heiskanen, R
- Rouvinen-Lagerström, N
- Merisalo-Soikkeli, M
- Hakonen, T
- Joensuu, T
- Kanerva, A
- Pesonen, S
- Hemminki, A
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Bramante, S., Koski, A., Kipar, A., Diaconu, I., Liikanen, I., Hemminki, O., Vassilev, L., Parviainen, S., Cerullo, V., Pesonen, S. K., Oksanen, M., Heiskanen, R., Rouvinen-Lagerström, N., Merisalo-Soikkeli, M., Hakonen, T., Joensuu, T., Kanerva, A., Pesonen, S., & Hemminki, A. (2014). Serotype chimeric oncolytic adenovirus coding for GM-CSF for treatment of sarcoma in rodents and humans. International Journal of Cancer, 135, 720–730. https://doi.org/10.1002/ijc.28696
