Publication: Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice
Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice
Date
Date
Date
Citations
Yalamanoglu, A., Dubach, I. L., Schulthess, N., Ingoglia, G., Swindle, D. C., Humar, R., Schaer, D. J., Buehler, P. W., Irwin, D. C., & Vallelian, F. (2021). Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice. Frontiers in Immunology, 12, 627944. https://doi.org/10.3389/fimmu.2021.627944
Abstract
Abstract
Abstract
Sickle cell disease (SCD) is an inherited hemolytic disorder, defined by a point mutation in the β-globin gene. Stress conditions such as infection, inflammation, dehydration, and hypoxia trigger erythrocyte sickling. Sickled red blood cells (RBCs) hemolyze more rapidly, show impaired deformability, and increased adhesive properties to the endothelium. In a proinflammatory, pro-coagulative environment with preexisting endothelial dysfunction, sickled RBCs promote vascular occlusion. Hepatobiliary involvement related to the sickling pr
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Yalamanoglu, Ayla
- Dubach, Irina L
- Schulthess, Nadja
- Ingoglia, Giada
- Swindle, Delaney C
- Humar, Rok
- Schaer, Dominik J
- Buehler, Paul W
- Irwin, David C
- Vallelian, Florence
Volume
Volume
Volume
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Yalamanoglu, A., Dubach, I. L., Schulthess, N., Ingoglia, G., Swindle, D. C., Humar, R., Schaer, D. J., Buehler, P. W., Irwin, D. C., & Vallelian, F. (2021). Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice. Frontiers in Immunology, 12, 627944. https://doi.org/10.3389/fimmu.2021.627944
