Publication: Synthesis of Colibactin Pyrrolidono[3,4-d]pyridones via Regioselective C(sp3)–H Activation
Synthesis of Colibactin Pyrrolidono[3,4-d]pyridones via Regioselective C(sp3)–H Activation
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Ilazi, A., Huang, B., de Almeida Campos, V., & Gademann, K. (2020). Synthesis of Colibactin Pyrrolidono[3,4-d]pyridones via Regioselective C(sp3)–H Activation. Organic Letters, 22(17), 6858–6862. https://doi.org/10.1021/acs.orglett.0c02385
Abstract
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Abstract
The synthesis of pyrrolidono[3,4-d]pyridones of relevance to putative genotoxic colibactin structures featuring a doubly conjugated 1,6-Michael acceptor system is reported. We investigated and implemented a highly selective Pd-catalyzed C(sp3)–H activation reaction as a key step and further functionalized the pyridone core. Evaluating the role of this structural unit of relevance to colibactin, we found that this structure displayed a high degree of stability toward both acidic conditions and nucleophiles.
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- Ilazi, Agron
- Huang, Bin
- de Almeida Campos, Valery
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Ilazi, A., Huang, B., de Almeida Campos, V., & Gademann, K. (2020). Synthesis of Colibactin Pyrrolidono[3,4-d]pyridones via Regioselective C(sp3)–H Activation. Organic Letters, 22(17), 6858–6862. https://doi.org/10.1021/acs.orglett.0c02385
