EEG-fMRI Signal Coupling Is Modulated in Subjects With Mild Cognitive Impairment and Amyloid Deposition

Michels, Lars; Riese, Florian; Meyer, Rafael; Kälin, Andrea M; Leh, Sandra E; Unschuld, Paul G; Luechinger, Roger; Hock, Christoph; O'Gorman, Ruth; Kollias, Spyros; Gietl, Anton F

doi:10.3389/fnagi.2021.631172

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Michels, L., Riese, F., Meyer, R., Kälin, A. M., Leh, S. E., Unschuld, P. G., Luechinger, R., Hock, C., O’Gorman, R., Kollias, S., & Gietl, A. F. (2021). EEG-fMRI Signal Coupling Is Modulated in Subjects With Mild Cognitive Impairment and Amyloid Deposition. Frontiers in Aging Neuroscience, 13, 631172. https://doi.org/10.3389/fnagi.2021.631172

Abstract

Cognitive impairment indicates disturbed brain physiology which can be due to various mechanisms including Alzheimer's pathology. Combined functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) recordings (EEG-fMRI) can assess the interplay between complementary measures of brain activity and EEG changes to be localized to specific brain regions. We used a two-step approach, where we first examined changes related to a syndrome of mild cognitive impairment irrespective of pathology and then studied the specific