A concept for anisotropic PTV margins including rotational setup uncertainties and its impact on the tumor control probability in canine brain tumors

Radonic, Stephan; Besserer, Jürgen; Rohrer Bley, Carla; Schneider, Uwe; Meier, Valeria

doi:10.1088/2057-1976/ac8a9f

Citations

Citation copied

Radonic, S., Besserer, J., Rohrer Bley, C., Schneider, U., & Meier, V. (2022). A concept for anisotropic PTV margins including rotational setup uncertainties and its impact on the tumor control probability in canine brain tumors. Biomedical Physics & Engineering Express, 8(6), 065006. https://doi.org/10.1088/2057-1976/ac8a9f

Abstract

Objective In this modelling study, we pursued two main goals. The first was to establish a new CTV-to-PTV expansion which considers the closest and most critical organ at risk (OAR). The second goal was to investigate the impact of the planning target volume (PTV) margin size on the tumor control probability (TCP) and its dependence on the geometrical setup uncertainties. The aim was to achieve a smaller margin expansion close to the OAR while allowing a moderately larger expansion in less critical areas further away from the OAR and