Publication: How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch
How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch
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Pagani, M., Albisetti, G. W., Sivakumar, N., Wildner, H., Santello, M., Johannssen, H. C., & Zeilhofer, H. U. (2019). How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch. Neuron, 103, 102-117.e5. https://doi.org/10.1016/j.neuron.2019.04.022
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Abstract
Spinal transmission of pruritoceptive (itch) signals requires transneuronal signaling by gastrin-releasing peptide (GRP) produced by a subpopulation of dorsal horn excitatory interneurons. These neurons also express the glutamatergic marker vGluT2, raising the question of why glutamate alone is insufficient for spinal itch relay. Using optogenetics together with slice electrophysiology and mouse behavior, we demonstrate that baseline synaptic coupling between GRP and GRP receptor (GRPR) neurons is too weak for suprathreshold excitatio
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- Pagani, Martina
- Albisetti, Gioele W
- Sivakumar, Nandhini
- Wildner, Hendrik
- Santello, Mirko
- Johannssen, Helge C
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Pagani, M., Albisetti, G. W., Sivakumar, N., Wildner, H., Santello, M., Johannssen, H. C., & Zeilhofer, H. U. (2019). How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch. Neuron, 103, 102-117.e5. https://doi.org/10.1016/j.neuron.2019.04.022
