Publication: Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice
Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice
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Wang, S., Lee, K., Gray, S., Zhang, Y., Tang, C., Morrish, R. B., Tosti, E., van Oers, J., Amin, M. R., Cohen, P. E., MacCarthy, T., Roa, S., Scharff, M. D., Edelmann, W., & Chahwan, R. (2022). Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice. Nucleic Acids Research, 50(14), 8093–8106. https://doi.org/10.1093/nar/gkac616
Abstract
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Abstract
DNA damage response pathways rely extensively on nuclease activity to process DNA intermediates. Exonuclease 1 (EXO1) is a pleiotropic evolutionary conserved DNA exonuclease involved in various DNA repair pathways, replication, antibody diversification, and meiosis. But, whether EXO1 facilitates these DNA metabolic processes through its enzymatic or scaffolding functions remains unclear. Here, we dissect the contribution of EXO1 enzymatic versus scaffolding activity by comparing Exo1DA/DA mice expressing a proven nuclease-dead mutant
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- Wang, Shanzhi
- Lee, Kyeryoung
- Gray, Stephen
- Zhang, Yongwei
- Tang, Catherine
- Morrish, Rikke B
- Tosti, Elena
- van Oers, Johanna
- Amin, Mohammad Ruhul
- Cohen, Paula E
- MacCarthy, Thomas
- Roa, Sergio
- Scharff, Matthew D
- Edelmann, Winfried
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Wang, S., Lee, K., Gray, S., Zhang, Y., Tang, C., Morrish, R. B., Tosti, E., van Oers, J., Amin, M. R., Cohen, P. E., MacCarthy, T., Roa, S., Scharff, M. D., Edelmann, W., & Chahwan, R. (2022). Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice. Nucleic Acids Research, 50(14), 8093–8106. https://doi.org/10.1093/nar/gkac616
