Publication: Epicardial fibrosis explains increased endo-epicardial dissociation and epicardial breakthroughs in human atrial fibrillation
Epicardial fibrosis explains increased endo-epicardial dissociation and epicardial breakthroughs in human atrial fibrillation
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Gharaviri, A., Bidar, E., Potse, M., Zeemering, S., Verheule, S., Pezzuto, S., Krause, R., Maessen, J. G., Auricchio, A., & Schotten, U. (2020). Epicardial fibrosis explains increased endo-epicardial dissociation and epicardial breakthroughs in human atrial fibrillation. Frontiers in Physiology, 11, 68. https://doi.org/10.3389/fphys.2020.00068
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Background: Atrial fibrillation (AF) is accompanied by progressive epicardial fibrosis, dissociation of electrical activity between the epicardial layer and the endocardial bundle network, and transmural conduction (breakthroughs). However, causal relationships between these phenomena have not been demonstrated yet. Our goal was to test the hypothesis that epicardial fibrosis suffices to increase endo-epicardial dissociation (EED) and breakthroughs (BT) during AF. Methods: We simulated the effect of fibrosis in the epicardial layer on
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- Gharaviri, Ali
- Bidar, Elham
- Potse, Mark
- Zeemering, Stef
- Verheule, Sander
- Pezzuto, Simone
- Krause, Rolf
- Maessen, Jos G
- Auricchio, Angelo
- Schotten, Ulrich
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Gharaviri, A., Bidar, E., Potse, M., Zeemering, S., Verheule, S., Pezzuto, S., Krause, R., Maessen, J. G., Auricchio, A., & Schotten, U. (2020). Epicardial fibrosis explains increased endo-epicardial dissociation and epicardial breakthroughs in human atrial fibrillation. Frontiers in Physiology, 11, 68. https://doi.org/10.3389/fphys.2020.00068
