Publication: Blocking gephyrin phosphorylation or microglia BDNF signaling prevents synapse loss and reduces infarct volume after ischemia
Blocking gephyrin phosphorylation or microglia BDNF signaling prevents synapse loss and reduces infarct volume after ischemia
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Cramer, T., Gill, R., Thirouin, Z. S., Vaas, M., Sampath, S., Martineau, F., Noya, S. B., Colameo, D., Chang, P. K.-Y., Wu, P., Barker, P. A., Brown, S. A., Paolicelli, R. C., Klohs, J., McKinney, R. A., & Tyagarajan, S. K. (2020). Blocking gephyrin phosphorylation or microglia BDNF signaling prevents synapse loss and reduces infarct volume after ischemia (No. 055087; ArXiv.Org). https://doi.org/10.1101/2020.04.22.055087
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Microglia interact with neurons to facilitate synapse plasticity; however, signal transducers between microglia and neuron remain unknown. Here, using in vitro organotypic hippocampal slice cultures and transient MCAO in genetically-engineered mice in vivo, we report that at 24 h post-ischemia microglia release BDNF to downregulate glutamatergic and GABAergic synapses within the peri-infarct area. Analysis of the CA1 hippocampal formation in vitro shows that proBDNF and mBDNF downregulate glutamatergic dendritic spines and gephyrin sc
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Cramer, T., Gill, R., Thirouin, Z. S., Vaas, M., Sampath, S., Martineau, F., Noya, S. B., Colameo, D., Chang, P. K.-Y., Wu, P., Barker, P. A., Brown, S. A., Paolicelli, R. C., Klohs, J., McKinney, R. A., & Tyagarajan, S. K. (2020). Blocking gephyrin phosphorylation or microglia BDNF signaling prevents synapse loss and reduces infarct volume after ischemia (No. 055087; ArXiv.Org). https://doi.org/10.1101/2020.04.22.055087
