Publication: Intercalation-enhanced “Click” Crosslinking of DNA
Intercalation-enhanced “Click” Crosslinking of DNA
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Tera, M., Harati Taji, Z., & Luedtke, N. W. (2018). Intercalation-enhanced “Click” Crosslinking of DNA. Angewandte Chemie, 130(47), 15631–15635. https://doi.org/10.1002/ange.201808054
Abstract
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Abstract
DNA–DNA cross‐linking agents constitute an important family of chemotherapeutics that non‐specifically react with endogenous nucleophiles and therefore exhibit undesirable side effects. Here we report a cationic Sondheimer diyne derivative “DiMOC” that exhibits weak, reversible intercalation into duplex DNA (Kd=15 μm) where it undergoes tandem strain‐promoted cross‐linking of azide‐containing DNA to give DNA‐DNA interstrand crosslinks (ICLs) with an exceptionally high apparent rate constant kapp=2.1×105 m−1 s−1. This represents a 21 0
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Creators (Authors)
- Tera, Masayuki
- Harati Taji, Zahra
- Luedtke, Nathan W
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Dr. Helmut Legerlotz‐Stiftung
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Tera, M., Harati Taji, Z., & Luedtke, N. W. (2018). Intercalation-enhanced “Click” Crosslinking of DNA. Angewandte Chemie, 130(47), 15631–15635. https://doi.org/10.1002/ange.201808054