Publication: Early and Long-Term Effects of Dupilumab Treatment on Circulating T-Cell Functions in Patients with Moderate-to-Severe Atopic Dermatitis
Early and Long-Term Effects of Dupilumab Treatment on Circulating T-Cell Functions in Patients with Moderate-to-Severe Atopic Dermatitis
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Bakker, D. S., van der Wal, M. M., Heeb, L. E. M., Giovannone, B., Asamoah, M., Delemarre, E. M., Drylewicz, J., Nierkens, S., Boyman, O., de Bruin-Weller, M. S., Thijs, J. L., & van Wijk, F. (2021). Early and Long-Term Effects of Dupilumab Treatment on Circulating T-Cell Functions in Patients with Moderate-to-Severe Atopic Dermatitis. Journal of Investigative Dermatology, 141, 1943-1953.e13. https://doi.org/10.1016/j.jid.2021.01.022
Abstract
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Abstract
Dupilumab, a mAb targeting IL-4 receptor alpha (IL-4Rα), markedly improves disease severity in patients with atopic dermatitis. However, the effect of IL-4Rα blockade on dynamics of circulating skin-homing T cells, which are crucial players in the pathologic mechanism of atopic dermatitis, has not been studied yet. In addition, it remains unknown whether dupilumab treatment induces long-lasting T- and B-cell polarization. Therefore, we studied the short- and long-term effects of dupilumab treatment on IL-4Rα expression and T-cell cyto
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- Bakker, Daphne S
- van der Wal, Maria M
- Heeb, Lukas E M
- Giovannone, Barbara
- Asamoah, Mindy
- Delemarre, Eveline M
- Drylewicz, Julia
- Nierkens, Stefan
- Boyman, Onur
- de Bruin-Weller, Marjolein S
- Thijs, Judith L
- van Wijk, Femke
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Bakker, D. S., van der Wal, M. M., Heeb, L. E. M., Giovannone, B., Asamoah, M., Delemarre, E. M., Drylewicz, J., Nierkens, S., Boyman, O., de Bruin-Weller, M. S., Thijs, J. L., & van Wijk, F. (2021). Early and Long-Term Effects of Dupilumab Treatment on Circulating T-Cell Functions in Patients with Moderate-to-Severe Atopic Dermatitis. Journal of Investigative Dermatology, 141, 1943-1953.e13. https://doi.org/10.1016/j.jid.2021.01.022
