Publication: Macrolactonolides: a novel class of anti-inflammatory compounds
Macrolactonolides: a novel class of anti-inflammatory compounds
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Tomašković, L., Komac, M., Makaruha Stegić, O., Munić, V., Ralić, J., Stanić, B., Banjanac, M., Marković, S., Hrvačić, B., Čipčić Paljetak, H., Padovan, J., Glojnarić, I., Eraković Haber, V., Mesić, M., & Merćep, M. (2013). Macrolactonolides: a novel class of anti-inflammatory compounds. Bioorganic & Medicinal Chemistry, 21(1), 321–332. https://doi.org/10.1016/j.bmc.2012.10.036
Abstract
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A new concept in design of safe glucocorticoid therapy was introduced by conjugating potent glucocorticoid steroids with macrolides (macrolactonolides). These compounds were synthesized from various steroid 17β-carboxylic acids and 9a-N-(3-aminoalkyl) derivatives of 9-deokso-9a-aza-9a-homoeritromicin A and 3-descladinosyl-9-deokso-9a-aza-9a-homoeritromicin A using stable alkyl chain. Combining property of macrolides to preferentially accumulate in immune cells, especially in phagocyte cells, with anti-inflammatory activity of classic
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Creators (Authors)
- Tomašković, Linda
- Komac, Marijana
- Makaruha Stegić, Oresta
- Munić, Vesna
- Ralić, Jovica
- Stanić, Barbara
- Banjanac, Mihailo
- Marković, Stribor
- Hrvačić, Boška
- Čipčić Paljetak, Hana
- Padovan, Jasna
- Glojnarić, Ines
- Eraković Haber, Vesna
- Mesić, Milan
- Merćep, Mladen
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Tomašković, L., Komac, M., Makaruha Stegić, O., Munić, V., Ralić, J., Stanić, B., Banjanac, M., Marković, S., Hrvačić, B., Čipčić Paljetak, H., Padovan, J., Glojnarić, I., Eraković Haber, V., Mesić, M., & Merćep, M. (2013). Macrolactonolides: a novel class of anti-inflammatory compounds. Bioorganic & Medicinal Chemistry, 21(1), 321–332. https://doi.org/10.1016/j.bmc.2012.10.036