Publication: Metalloproteinases facilitate connection of wound bed vessels to pre-existing skin graft vasculature
Metalloproteinases facilitate connection of wound bed vessels to pre-existing skin graft vasculature
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Knapik, A., Hegland, N., Calcagni, M., Althaus, M., Vollmar, B., Giovanoli, P., & Lindenblatt, N. (2012). Metalloproteinases facilitate connection of wound bed vessels to pre-existing skin graft vasculature. Microvascular Research, 84, 16–23. https://doi.org/10.1016/j.mvr.2012.04.001
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BACKGROUND: Despite advances in tissue engineering of human skin, the exact revascularization processes remain unclear. Therefore it was the aim of this study to investigate the vascular transformations during engraftment and to identify associated proteolytic factors. METHODS: The modified dorsal skinfold chamber with autologous skin grafting was prepared in C57BL/6J mice, and intravital microscopy was performed. The expression of proteases and vascular factors was quantified by immunohistochemistry. RESULTS: Reperfusion of the skin
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- Knapik, Alicia
- Hegland, Niels
- Calcagni, Maurizio
- Althaus, Martina
- Vollmar, Brigitte
- Giovanoli, Pietro
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Knapik, A., Hegland, N., Calcagni, M., Althaus, M., Vollmar, B., Giovanoli, P., & Lindenblatt, N. (2012). Metalloproteinases facilitate connection of wound bed vessels to pre-existing skin graft vasculature. Microvascular Research, 84, 16–23. https://doi.org/10.1016/j.mvr.2012.04.001